Principal Investigator - Medical Readiness Systems Biology

Full Time
Silver Spring, MD 20910
Posted
Job description

Overview

About The Geneva Foundation

The Geneva Foundation is a 501(c)3 nonprofit established in 1993 with the purpose to ensure optimal health for service members and the communities they serve. This purpose is accomplished through our mission to advance military medicine through research, development, and education. Our culture is living our core values that focus on a higher purpose. Geneva serves a diverse population and is committed to making diversity, equity, inclusion and belonging a central focus of the employee experience. As a leader in military medical research, we develop critical lifesaving solutions for the global community – and build rewarding careers for our employees.

About The Position

The Principal Investigator is focused on research and development of solutions that address capability gaps existing at all levels of care. Medical Readiness Systems Biology (MRSB) is a disease-agnostic program that utilizes high-throughput, multi-omics platforms supported by a suite of cutting edge, targeted assay tools and Artificial Intelligence (AI)-driven analytical capabilities to identify diagnostic and prognostic biomarkers that generate a knowledge base about biological mechanisms and personalized care. MRSB is committed to developing a seamless, integrative module enabling to interrogate genome-to-phenome landscape to inform medical interventions and develop products to improve Warfighter health, performance, resilience, and readiness.

Responsibilities

  • Identify and characterize biomarkers for fifteen different projects to include: PTSD clinical and pre-clinical systems research, systems biology of coagulopathy research, polytrauma research, pain management research, musculoskeletal issues research, wound healing research, thermal injury, open-air burn pit smoke exposure research, radiation research, malaria research, hemorrhagic shock research, infectious diseases research, Traumatic Brain Injury (TBI) research, multiple stressors and animal model nutritional intervention, and sepsis research
  • Perform molecular analysis after multiple interventions
  • Assist in diagnosis, prognosis, and therapeutic choices
  • Determine differential expression through Transcriptomic analysis such as Microarrays/next generation sequencing, epigenetic analysis including DNA methylation and miRNA analysis, high throughput proteomics, exome Sequencing, whole genome arrays, and using tools such as R programming, Bioconductor, Ingenuity Pathway Analysis, and Genespring
  • Use Western blot/ELISA, molecular and system biology techniques nucleic acid and protein extractions with quality check, PCR, microbiome, metabolomics, pyrosequencing, statistics and data analysis and visualizations
  • Gather and analyze data resulting from the collaborative research to be used for identifying disease protein profiles and biochemical and metabolic changes to complete the clinical characterization, as well as metagenomics/microbiome sequencing
  • Identify the interrelated networks and pathways, as well as characterize the molecular signatures of PTSD disease progression/disease state and candidate biomarkers
  • Participate in research and development activites
  • Utilize established mathematical and scientific techniques to compile and analyze data
  • Write technical reports detailing procedures, outcomes, and observations
  • Promote safety and confidentiality of research participants at all times when working with human research studies
  • Promote humane and ethical treatment of animal subjects when working with animal research studies
  • Adhere to Occupational Safety and Health Administration (OSHA), Good Laboratory Practices (GLP) and Good Clinical Practices (GCP)
  • Maintain a collaborative research environment with all site personnel, research participants, The Geneva Foundation, and the prime partner organization

Qualifications

  • Master’s degree in Behavioral Science required
  • 5+ years of experience in the field or in a related area
  • 5+ years knowledge and experience with Department of Defense contracts administration and management, preferred
  • 5+ years medical research project management experience strongly desired, preferably with Department of Defense
  • Knowledge of commonly-used concepts, practices, and procedures within behavioral science, or similar field
  • Must be proficient in statistical analyses
  • Relies on instructions and pre-established guidelines to perform the functions of the job
  • Education and training commensurate with research protocol being conducted
  • Experience with advanced medical technologies preferred
  • Demonstrate competence in oral and written communication
  • Must be organized, attentive to detail, and possess a positive, friendly, and professional demeanor
  • Ability to be flexible with changing priorities and available to interact with employees, clients, and sponsors at all levels
  • Ability to exercise independent judgment in fast-paced, high-pressured environment with strict deadlines and to manage multiple projects
  • Ability to develop strong trusting relationships to gain support and achieve results
  • Computer skills, including at least intermediate experience with Excel and other Microsoft Office software

Job Type: Full-time

Pay: From $75,000.00 per year

Benefits:

  • Dental insurance
  • Flexible schedule
  • Health insurance
  • Life insurance
  • Paid time off
  • Vision insurance

Schedule:

  • 8 hour shift
  • Weekend availability

Ability to commute/relocate:

  • Silver Spring, MD 20910: Reliably commute or planning to relocate before starting work (Required)

Education:

  • Master's (Preferred)

Experience:

  • research: 4 years (Required)
  • DoD or federal grants/contracts: 3 years (Required)

Work Location: In person

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